With the Colts, Tittle was named the AAFC Rookie of the Year in 1948 after leading the team to the AAFC playoffs. After back-to-back one-win seasons, the Colts franchise folded, which allowed Tittle to be drafted in the 1951 NFL Draft by the 49ers. Through ten seasons in San Francisco, he was invited to four Pro Bowls, led the league in touchdown passes in 1955, and was named the NFL Player of the Year by the United Press in 1957. A groundbreaker, Tittle was part of the 49ers' famed "Million Dollar Backfield", was the first professional football player featured on the cover of Sports Illustrated, and is credited with coining "alley-oop" as a sports term. He retired as the NFL's all-time leader in passing yards, passing touchdowns, attempts, completions, and games played. Tittle was inducted into the Pro Football Hall of Fame in 1971, and his jersey number 14 is retired by the Giants.

This October 10, 1948 Baltimore Colts Vs. San Francisco 49ers program has been signed by Tittle with his full name and number, Yelberton Abraham Tittle, Jr. #63. This program is in great condition and includes a COA from Schwartz Sports.