Mussina spent his entire career in the American League East, won at least 11 games in 17 consecutive seasons – an American League record – and recorded a career .638 winning percentage. Among pitchers, he ranks 33rd in all-time wins (270), 33rd in games started (535), 66th in innings pitched (3,562.2), 19th in strikeouts (2,813), and 23rd all-time in pitching Wins Above Replacement (82.9). A five-time All-Star and seven-time Gold Glove winner, Mussina's consistency resulted in six top-five finishes in the voting for his league's Cy Young Award. He was elected to the National Baseball Hall of Fame in 2019.

This Rawlings official American League baseball was signed in black by Mussina and includes a Great Moments COA.