In 2010, McCoy took over as the starting running back for the Eagles, and broke the 1,000 yard rushing barrier. In 2011, McCoy was named First team All-Pro by the Associated Press. Then, in 2013, McCoy led the NFL in rushing yards with 1,607 rushing yards as of Week 17, shattering the team's individual single-season rushing yards record that stood for 34 years. McCoy went on to become the all-time leading rusher for the Eagles after the 2014 season, breaking the record previously held by Wilbert Montgomery.

In the 2015 offseason, McCoy was traded to the Buffalo Bills for linebacker Kiko Alonso. McCoy made the Pro Bowl in each of his first three years in Buffalo, helping the team snap a 17-year playoff drought, and has become one of a few select NFL running backs to surpass 10,000 career rushing yards. After playing four seasons with the Bills, he was released prior to the 2019 season and signed with Kansas City.

This Riddell Philadelphia Eagles full size helmet was signed in silver by McCoy and includes a Great Moments hologram and COA.