Mussina spent his entire career in the competitive and high-scoring American League East, won at least 11 games in 17 consecutive seasons – an American League record – and recorded a career .638 winning percentage. Among pitchers, he ranks 33rd in all-time wins (270), 33rd in games started (535), 66th in innings pitched (3,562.2), and 19th in strikeouts (2,813). A five-time All-Star and seven-time Gold Glove winner, Mussina's consistency resulted in six top-five finishes in the voting for his league's Cy Young Award.

This Rawlings official MLB baseball was signed in blue by Mussina and includes a MLB hologram.