Murray was selected by the Baltimore Orioles in the third round of the 1973 amateur draft and had several successful seasons in the minor leagues. He debuted at the major league level on April 7, 1977 and played in 160 games for the Orioles in his first season. He won the American League Rookie of the Year award by batting .283, hitting 27 home runs and contributing 88 RBI.

On September 6, 1996, Eddie Murray hit his 500th career home run—fittingly, the home run came as a member of the Orioles, and also came exactly one year to the day that Ripken had broken Lou Gehrig's streak of 2,130 consecutive games played. He retired after the 1997 season with 504 home runs; Mickey Mantle is the only switch-hitter who has hit more home runs.

This large Winning Streak Eddie Murray 2003 Hall of Fame pennant measures 17.5" x 40" and is individually numbered #78/100.