LaRussa ranks third in major league history in victories (2,728), trailing only Connie Mack (3,731) and John McGraw (2,763). He managed 5,097 games, joining Mack as the second manager or coach in American sports history to reach 5,000 games. In 2004, he became the sixth manager in history to win pennants with both American and National League teams; in 2006 he became the first manager ever to win multiple pennants in both leagues and the second manager to win the World Series in both leagues. LaRussa has also joined Mack as the second manager to win World Series titles in three decades and to win pennants in four. He is one of only four managers to be named Manager of the Year in both of baseball's major leagues. In November 2017, the Boston Red Sox announced that La Russa had joined the team as vice president and special assistant to Dave Dombrowski, the president of baseball operations.

This Rawlings official MLB baseball was signed in blue by LaRussa and inscribed, "2018 W.S. Champs" and "Boston Strong." This baseball includes a JSA sticker and COA.