Up in Smoke is a 1978 American stoner film directed by Lou Adler and starring Cheech Marin, Tommy Chong, Edie Adams, Strother Martin, Stacy Keach, and Tom Skerritt. It is Cheech & Chong's first feature-length film.

Cheech & Chong had been a counterculture comedy team for about ten years before they started reworking some of their material for their first film. Much of the film was shot in Los Angeles, California, including scenes set in Tijuana, while scenes set on the Mexican border were actually filmed at the border in Yuma, Arizona. While negatively received upon its release, Up in Smoke is credited with establishing the stoner film genre and is now considered a classic.

This "Up in Smoke" movie script was signed in green by Cheech Marin and Tommy Chong. It includes a JSA sticker and COA.