During his rookie season, the Yanks became the Dallas Texans, which became the Baltimore Colts in 1953. Marchetti played 13 seasons with the Colts and helped them win NFL Championships in 1958 and 1959. During his career, he was noted for being effective against the run and a relentless pass-rusher. He was voted "the greatest defensive end in pro football history" by the Pro Football Hall of Fame in 1972.

This Baltimore Colts full size Pro Line helmet was signed in blue by Marchetti and inscribed, "HOF 72." This helmet includes a Great Moments COA.