Manziel was launched into the national scene after he led Texas A&M to a 29–24 victory over No. 1 Alabama in Tuscaloosa. In that game, Manziel accounted for 345 of A&M's 418 yards of offense, including two passing touchdowns. In the following days, Manziel became the frontrunner for the Heisman Trophy in most national watch lists and polls due to his performance during the game combined with other Heisman frontrunners faltering. On November 24, during the game against the Missouri Tigers before a home crowd, Manziel left the game with an apparent knee injury late in the first quarter. He returned to the field for the next series of downs wearing a knee brace and finished the game with 439 yards of total offense, including 3 passing and 2 rushing touchdowns. During the game, he broke the single-season record for offensive production in the SEC with 4,600 yards, surpassing Cam Newton and Tim Tebow, notable recent Heisman Trophy winners. He also became the first freshman and only the fifth player in NCAA history to pass for 3000 and rush for 1,000 yards in a season, reaching that mark two games earlier than any other player. He won the SEC Freshman of the Year Award and College Football Performance National Freshman of the Year Award. Manziel won the Davey O'Brien Award on December 6 and the Heisman Trophy on December 8, making him the first freshman ever to win either award.

This custom Texas A&M jersey was signed in black by Manziel and includes a JSA sticker and COA.