Fisk is best known for "waving fair" his game-winning home run in the 12th inning of Game 6 of the 1975 World Series. At the time of his retirement in 1993, he held the record for most home runs all-time by a catcher with 351 (since passed by Mike Piazza). Fisk held the record for most games played at the position of catcher (2,226) until June 17, 2009 when he was surpassed by Iván Rodríguez. He still holds the American League record for most years served behind the plate with 24. Fisk was voted to the All-Star team 11 times and won three Silver Slugger Awards which is awarded annually to the best offensive player at each position. He was elected to the Hall of Fame in 2000.

This Rawlings official 1991 Comiskey Park Inaugural Year American League baseball was signed in blue by Fisk and includes a JSA sticker and COA.