Brown was taken in the first round of the 1957 draft by the Cleveland Browns. He departed as the NFL record holder for both single-season (1,863 in 1963) and career rushing (12,312 yards), as well as the all-time leader in rushing touchdowns (106), total touchdowns (126), and all-purpose yards (15,549). He was the first player ever to reach the 100-rushing-touchdowns milestone, and only a few others have done so since, despite the league's expansion to a 16-game season in 1978 (Brown's first four seasons were only 12 games, and his last five were 14 games). Brown's record of scoring 100 touchdowns in only 93 games stood until LaDainian Tomlinson did it in 89 games during the 2006 season. Brown holds the record for total seasons leading the NFL in all-purpose yards (5: 1958–1961, 1964), and is the only rusher in NFL history to average over 100 yards per game for a career. In addition to his rushing, Brown was a superb receiver out of the backfield, catching 262 passes for 2,499 yards and 20 touchdowns, while also adding another 628 yards returning kickoffs. Every season he played, Brown was voted into the Pro Bowl, and he left the league in style by scoring three touchdowns in his final Pro Bowl game. Perhaps the most amazing feat is that Jim Brown accomplished these records despite never playing past 29 years of age.

This Cleveland Browns jersey has been signed in black by Jim Brown and inscribed "HOF 71." This jersey includes a Great Moments hologram and COA.